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Clozapine may be the one accessible treatment for refractory schizophrenia however its use entails frequent bodily contact with healthcare employees for the purpose of required blood monitoring. To protect in opposition to the chance and severity of respiratory contamination, we advocate using vitamin D in all clozapine patients. Initiation of clozapine is probably going to stay problematic whereas the risk of contamination stays, given the degree of bodily contact required to assure security. Probably the most incessantly reported symptoms of COVID-19 contamination are fever, cough, myalgia, fatigue and shortness of breath. 15 Signs and symptoms of clozapine-related neutropenic sepsis embody a fever, flu-like symptoms, rigors and malaise.26 The overlap of the symptom of fever between these two situations means that rapid differential analysis is essential. We due to this fact remind prescribers that every one patients who take clozapine and present with fever and flu-like symptoms should have a blood sample taken instantly for BR102375 WCC and ANC, BR102375 alongside a coronavirus antigen swab test the place out there.
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